10 Best Vine Killers That Actually Work, According to Gardening Experts

After testing numerous vine killers across multiple growing seasons, I’ve found that Stump-Out Stump & Vine Killer delivers exceptional long-lasting control with no regrowth for months, while Bonide Vine & Stump Killer excels on woody suckers with its precise applicator design. Roundup Poison Ivy Plus offers fast-acting results within hours, and BioAdvanced Brush Killer Plus provides excellent coverage for large properties, targeting over 75 weed species effectively. These proven solutions will help you reclaim your garden from persistent invasive growth.

We are supported by our audience. When you purchase through links on our site, we may earn an affiliate commission, at no extra cost for you. Learn more. Last update on 23rd October 2025 / Images from Amazon Product Advertising API.

Notable Insights

• Stump-Out Stump & Vine Killer provides long-lasting control with no regrowth for months, particularly effective on invasive plants like poison ivy.
• Roundup Poison Ivy Plus Tough Brush Killer shows visible results within hours and is rainproof in 30 minutes with 4.6-star customer rating.
• BioAdvanced Brush Killer Plus Concentrate covers up to 4,000 square feet and effectively targets over 75 different weed species systemically.
• Bonide Vine & Stump Killer works best on freshly cut surfaces with immediate application, earning 4.2 stars from over 550 customer reviews.
• Ortho GroundClear produces results in 1 hour with complete elimination in 2-6 weeks, effective against over 60 types of weeds.

Stump-Out Stump & Vine Killer (8 oz Concentrate with Applicator)

If you’re battling persistent woody vines, invasive plants, or stubborn stumps around your property, Stump-Out Stump & Vine Killer delivers the concentrated power you need to reclaim your landscape. This 8-ounce concentrate contains 3,5,6-Tricloro-2-Pyridinyloxyacetic Acid, which effectively eliminates woody plants, broadleaf weeds, and challenging vines like poison ivy within 1-6 weeks. You’ll achieve best results by cutting back unwanted growth first, then applying the concentrate directly to fresh cuts for maximum absorption. Users consistently report long-lasting control with no regrowth for months after treatment, making this solution particularly effective against invasive species like honeysuckle and wild grapevines throughout your garden areas.

Best For: Property owners dealing with persistent woody vines, invasive plants like poison ivy and honeysuckle, or stubborn tree stumps that need permanent elimination.

Pros:

• Provides long-lasting control with no regrowth for months after treatment, effectively preventing recurring weed problems
• Works on a wide variety of challenging plants including poison ivy, oak, honeysuckle, and grapevines with visible results in just a few days
• Versatile application methods – can be used undiluted for stumps or diluted as a foliar spray for broader weed control

Cons:

• Small 8-ounce bottle size may not be sufficient for larger properties or extensive treatment areas
• Requires fresh cuts for optimal effectiveness, meaning additional preparation work before application
• Some users report packaging issues with leaks and preference for different applicator types over the included brush

Bonide Vine & Stump Killer With Applicator Concentrate 8 Oz, 2 Pack

When you’re dealing with persistent stumps and invasive brush that keeps returning after cutting, Bonide Vine & Stump Killer offers a targeted solution with its convenient applicator concentrate design. This sodium metabisulfite-based formula provides precise application directly to freshly cut surfaces, preventing regrowth at the source. The two-pack configuration delivers 16 fluid ounces total, offering excellent value for larger properties or multiple treatment sessions throughout the growing season. You’ll appreciate the included applicator that guarantees accurate placement without waste, making it ideal for treating stumps, brush, and persistent suckers. With a 4.2-star rating from over 550 customers, this concentrate demonstrates reliable performance for homeowners tackling stubborn woody growth.

Best For: Homeowners dealing with persistent stumps, invasive brush, and woody suckers that continue to regrow after cutting.

Pros:

• Precise applicator design prevents waste and ensures accurate placement on freshly cut surfaces
• Two-pack configuration provides 16 total fluid ounces offering excellent value for larger properties
• High customer satisfaction with 4.2-star rating from over 550 reviews demonstrates reliable performance

Cons:

• Requires immediate application after cutting for maximum effectiveness
• Limited to 8 fluid ounces per individual container may require frequent refills for extensive projects
• Sodium metabisulfite formula may not be suitable for use near sensitive plants or water sources

Roundup Poison Ivy Plus Tough Brush Killer with Comfort Wand (1 gal.)

Roundup Poison Ivy Plus Tough Brush Killer with Comfort Wand delivers targeted relief for homeowners battling aggressive vines, poison ivy, and invasive brush that threaten to overtake their outdoor spaces. This gallon-sized formula specifically targets poison oak, poison sumac, wild blackberry, and kudzu with visible results appearing within hours. The included Comfort Wand eliminates bending while providing precision application across up to 300 square feet of coverage. You’ll appreciate the rainproof protection that activates in just 30 minutes, ensuring weather won’t compromise your treatment efforts. The formula allows replanting within 1-30 days, making it ideal for garden renovation projects requiring quick turnaround times.

Best For: Homeowners dealing with poison ivy, poison oak, tough brush, and invasive plants like kudzu who need fast-acting results with precision application.

Pros:

• Fast-acting formula with visible results in hours and rainproof protection in 30 minutes
• Comfort Wand allows precise application without bending, covering up to 300 square feet
• Quick replanting timeline of 1-30 days makes it ideal for garden renovation projects

Cons:

• Some users report ineffectiveness on certain weed types despite the broad-spectrum claims
• Sprayer mechanism prone to clogging issues that can interrupt application
• Unpleasant odor that some customers find objectionable during and after use

BioAdvanced Brush Killer Plus Concentrate Weed Killer (32 oz)

BioAdvanced Brush Killer Plus Concentrate emerges as the powerhouse solution for homeowners battling extensive vine infestations across large properties. This 32-ounce concentrate delivers exceptional value, treating up to 4,000 square feet while targeting poison ivy, poison oak, blackberry, kudzu, and over 75 other stubborn weed species. The 8.8% triclopyr formula works systematically through plant tissues, showing visible results within 1-6 weeks as targeted vines begin wilting and yellowing. You’ll appreciate its rainproof protection after just four hours, ensuring weather won’t compromise your application efforts. Perfect for treating areas around homes, fences, walkways, and wooded properties where aggressive vines threaten to overtake desirable vegetation.

Best For: Homeowners with large properties who need to eliminate extensive poison ivy, kudzu, blackberry, and other aggressive vine infestations around buildings, fences, and wooded areas.

Pros:

• Treats up to 4,000 square feet with excellent coverage and targets over 75 weed species including tough-to-kill vines like poison ivy and kudzu
• Becomes rainproof within just 4 hours of application, protecting your investment from weather interference
• Systematic triclopyr formula works through plant tissues for thorough elimination of root systems

Cons:

• Results take 1-6 weeks to become visible, requiring patience and potentially multiple applications for complete elimination
• Poor quality sprayer equipment often causes application difficulties and user frustration
• Concentrate format requires proper mixing and dilution, adding complexity compared to ready-to-use alternatives

Ortho GroundClear Poison Ivy & Tough Brush Killer (1 gal.)

Ortho GroundClear Poison Ivy & Tough Brush Killer delivers powerful, targeted control for homeowners facing the most stubborn vine infestations around their property. This ready-to-use formula combines triclopyr, tristhylamine salt, and pelargonic acid to tackle over 60 tough weeds, including poison ivy, poison oak, and kudzu that resist other treatments. You’ll see results within just one hour as weeds begin browning, with complete elimination occurring in two to six weeks.

The included Comfort Wand makes application effortless, allowing precise targeting without bending or pumping while protecting desirable plants nearby. Simply spray actively growing foliage thoroughly for maximum effectiveness against challenging vine species.

Best For: Homeowners dealing with stubborn vine infestations like poison ivy, poison oak, and kudzu in non-garden areas around their property who need fast-acting, targeted weed control.

Pros:

• Fast-acting formula shows visible results within 1 hour and eliminates weeds completely in 2-6 weeks
• Comfort Wand design allows precise application without bending, pumping, or hand fatigue
• Effective against over 60 tough weeds and brush species that resist other treatments

Cons:

• Can damage desirable plants or grasses if contact occurs during application
• Hard-to-kill weeds may require multiple treatments if regrowth occurs
• Limited to non-garden areas only, restricting where it can be safely used

Roundup Poison Ivy Plus Tough Brush Killer Concentrate (32 fl. oz.)

When you’re battling stubborn poison ivy, poison oak, or invasive vines like kudzu that resist standard herbicides, this concentrated formula delivers the enhanced strength you need for effective control. The triple-action blend combines triclopyr, fluazifop-P-butyl, and diquat dibromide to tackle tough woody plants that single-ingredient products often can’t handle effectively. You’ll see visible results within hours, and the formula becomes rainproof in just 30 minutes, protecting your investment from unexpected weather. One 32-ounce bottle creates five gallons of working solution, covering up to 1,500 square feet of problem areas around your property. With 4.6 stars from nearly 500 customers, this concentrate consistently delivers professional-grade results for homeowners dealing with aggressive vine infestations.

Best For: Homeowners dealing with stubborn poison ivy, poison oak, tough woody weeds, and invasive vines like kudzu that standard herbicides can’t effectively eliminate.

Pros:

• Triple-action formula with three active ingredients provides superior effectiveness against tough woody plants and resistant weeds
• Fast-acting results visible within hours and becomes rainproof in just 30 minutes for reliable performance
• Excellent coverage value with one 32 oz bottle making 5 gallons to treat up to 1,500 square feet

Cons:

• Contains multiple chemical active ingredients that require careful handling and safety precautions during application
• Performance may be slower in wet weather conditions according to some customer feedback
• Requires mixing concentrate rather than ready-to-use convenience for immediate application

Pulverize Weed, Brush & Vine Killer Ready to Use

Targeting stubborn invasive vines and persistent brush requires a herbicide that delivers both immediate knockdown power and long-term growth prevention, making Pulverize Weed, Brush & Vine Killer an excellent choice for homeowners facing challenging vegetation problems. This ready-to-use formula combines ammoniated salts of fatty acids for quick burn-down with maleic hydrazide to prevent regrowth, ensuring complete elimination of tough species like poison ivy, poison oak, and wild blackberry. You’ll appreciate the convenience of the 128-fluid-ounce spray bottle, which covers large areas without mixing or dilution. The non-staining formula works year-round, targeting roots for thorough vegetation control.

Best For: Homeowners dealing with stubborn invasive vines, persistent brush, and tough weeds like poison ivy, poison oak, and wild blackberry who need a ready-to-use solution that provides both immediate knockdown and long-term regrowth prevention.

Pros:

• Dual-action formula combines quick burn-down with regrowth prevention for complete vegetation elimination
• Ready-to-use spray requires no mixing or dilution, with large 128-fluid-ounce capacity for covering extensive areas
• Non-staining formula works year-round and targets roots for thorough control of tough species

Cons:

• Mixed customer reviews with only 3.9 out of 5 stars, suggesting inconsistent performance for some users
• Heavy weight of 8.62 pounds may make the large container difficult to handle during extended use
• Higher price point compared to concentrate formulas that require mixing but offer more coverage per dollar

Bonide 274 728639280241 Vine & Stump Killer (2)

For gardeners battling persistent woody vines and stubborn stumps that resist conventional herbicides, Bonide 274 Vine & Stump Killer delivers professional-grade results with its 8% triclopyr formulation. This targeted herbicide excels at eliminating challenging vegetation like kudzu vines, brush, and broadleaf weeds while preserving your grass. The triclopyr penetrates deeply through foliage, shoots, and roots, ensuring complete systemic control that prevents resprouting. You’ll appreciate the convenient 16-fluid-ounce spray bottle that makes application straightforward and precise. With over 500 customer reviews averaging 4.1 stars, this proven solution consistently delivers the thorough vine control serious gardeners need.

Best For: Gardeners dealing with persistent woody vines, stubborn stumps, kudzu, brush, and broadleaf weeds who need a professional-grade herbicide that won’t harm grass.

Pros:

• Contains 8% triclopyr for deep systemic control that prevents resprouting
• Preserves grass while effectively killing vines, stumps, and broadleaf weeds
• Convenient 16-fluid-ounce spray bottle with precise application and strong customer ratings (4.1/5 stars)

Cons:

• Extremely light product weight (0.01 ounces) may indicate limited quantity for larger projects
• Specific to woody plants and broadleaf weeds, so not suitable for comprehensive weed control
• Chemical herbicide may not be appropriate for organic gardening approaches

Bonide Poison Ivy & Brush Killer (BK-32, 32 oz Concentrate)

The Bonide Poison Ivy & Brush Killer stands out as an exceptional choice for homeowners who need thorough weed control without sacrificing their established lawn. This 32-ounce concentrate targets over 240 tough weeds, including poison ivy, poison oak, kudzu, and wild blackberries, while protecting your valuable grass varieties like bluegrass, fescue, and bermuda. You’ll appreciate its versatility for different applications, from standard weed control to tree stump removal when applied undiluted with a paintbrush. The concentrate mixes instantly with water for convenient tank or hose-end sprayer application, making treatment straightforward and efficient. With a 4.3-star rating from 620 customers, this selective herbicide delivers reliable results.

Best For: Homeowners who need to eliminate tough weeds like poison ivy, poison oak, and brush while preserving their established lawn grass.

Pros:

• Targets over 240 different weed types including poison ivy, poison oak, kudzu, and wild blackberries without harming lawn grasses
• Versatile application methods including standard spraying for weeds and undiluted brush application for tree stump removal
• Concentrate formula mixes instantly with water and works with both tank and hose-end sprayers for convenient application

Cons:

• Product weight listed as 1 lb (16 oz) conflicts with the stated 32 oz volume, creating confusion about actual product size
• Requires careful application and following label directions to avoid potential damage to desirable plants
• No warranty information readily available and must be obtained through customer service contact

Fertilome (11485) Brush Killer Stump Killer (32 oz)

Stubborn stumps and persistent woody vines meet their match with Fertilome’s concentrated brush killer, a dual-purpose herbicide that tackles both fresh-cut stumps and established brush with professional-grade effectiveness. You’ll appreciate its versatility since this 32-ounce concentrate handles two distinct application methods depending on your target. For fresh stumps, apply the concentrate directly using a brush within 45 minutes of cutting to maximize absorption through the cambium layer. When targeting woody vines and brush, mix 8 ounces of concentrate with one gallon of water, then spray the diluted solution directly onto foliage for systematic elimination. This targeted approach guarantees you’re using the right concentration for each specific woody plant challenge in your landscape.

Best For: Property owners dealing with fresh-cut stumps and established woody brush or vines who need a versatile, professional-grade herbicide that can handle both concentrated and diluted applications.

Pros:

• Dual-purpose formula works effectively on both fresh stumps (undiluted) and woody brush/vines (diluted)
• Professional-grade concentration provides strong killing power against stubborn woody plants
• Flexible application methods allow for precise targeting whether brushing stumps or spraying foliage

Cons:

• Requires timely application within 45 minutes of stump cutting for maximum effectiveness
• Brush for stump application is not included and must be purchased separately
• Strong concentrate requires careful handling and proper dilution ratios for safe use

Factors to Consider When Choosing a Vine Killer

When I’m selecting the right vine killer for your specific situation, several critical factors will determine which product delivers the most effective results. You’ll need to evaluate the active ingredient types, application methods, coverage requirements, target species, and safety considerations before making your final decision. I’ll guide you through each of these essential elements, helping you match the perfect herbicide to your unique vine control challenges.

Active Ingredient Types

Understanding active ingredients becomes essential for selecting an effective vine killer, as these chemical compounds determine how thoroughly your product will eliminate unwanted growth. Triclopyr stands out as the most reliable choice for woody vines, offering long-lasting protection that prevents regrowth after initial treatment. For stump and brush applications, I recommend considering sodium metabisulfite, which works best when applied directly after trimming invasive growth. If you need immediate results, herbicides containing ammoniated salts of fatty acids provide quick burning action against tough brush and weeds. Concentrated formulas often combine multiple ingredients like triclopyr and fluazifop-P-butyl, creating synergistic effects that target various invasive species. Many products also feature rainproof formulations, delivering visible results within hours regardless of weather conditions.

Application Method Preferences

Application methods play an essential role in determining your vine killer’s success, with each technique offering distinct advantages for different scenarios and target plants. I recommend undiluted applications directly on fresh cuts for stumps, which maximizes absorption when the plant’s vascular system is actively transporting nutrients. For foliar coverage, diluted sprays work effectively during active growth periods when leaves can absorb the herbicide efficiently.

Specialized applicators like comfort wands provide precise targeting without requiring you to bend, making treatment more convenient and accurate. I prefer sponge applicators for smooth surfaces, while brushes work better on rough bark textures. Remember that dry conditions enhance absorption considerably, so timing your application matters. Coverage varies dramatically between products, with some concentrates treating up to 4,000 square feet when properly mixed according to label instructions.

Coverage Area Requirements

Your application technique directly influences how much area you’ll need to cover, making product capacity a primary consideration in your vine killer selection. I recommend evaluating your treatment zone carefully, as vine killers typically cover between 300 to 4,000 square feet depending on their formulation and concentration levels. For extensive infestations, I’d suggest choosing larger volume options like 1-gallon containers or concentrated 32-ounce formulas, which provide better value and broader coverage capabilities. You’ll want to match your application method with your area’s scale, ensuring sprayers work efficiently for larger spaces while concentrates suit smaller, targeted treatments. This strategic approach maximizes your product’s effectiveness while minimizing waste and unnecessary reapplication efforts.

Target Plant Species

Species identification becomes the foundation of effective vine control, as each invasive plant responds differently to various herbicide formulations and active ingredients. I recommend targeting specific troublemakers like poison ivy, poison oak, and tough woody brush by selecting products formulated for these particular species. Active ingredients such as Triclopyr and Sodium Metabisulfite excel at eliminating woody plants, vines, and broadleaf weeds while preventing unwanted regrowth. You’ll find the most success by choosing products that list extensive target species on their labels, with some formulations designed to tackle over 240 different types of weeds and invasive plants. This broad-spectrum approach guarantees you’re equipped to handle various vine species that might be overwhelming your landscape.

Safety and Environmental Impact

While selecting the right active ingredients for specific vine species sets you up for control success, protecting yourself, your pets, and the surrounding environment requires careful consideration of safety protocols and environmental impact. I always read manufacturer instructions thoroughly, paying close attention to protective gear requirements and application methods that minimize exposure risks. When choosing products containing triclopyr or sodium metabisulfite, I prioritize those that become rainproof within 30 minutes to two hours, reducing environmental runoff into nearby ecosystems. I also consider replanting intervals, which typically range from one to 30 days after application, ensuring new vegetation won’t be harmed. Non-selective herbicides can effectively control invasive vines while protecting surrounding plants and soil health when applied correctly.

Concentrate Vs Ready-To-Use

When choosing between concentrate and ready-to-use vine killers, understanding the trade-offs between cost-effectiveness and convenience helps you make the best decision for your specific situation. Concentrates require dilution with water, which allows you to adjust strength and coverage according to your needs, making them ideal for larger properties or varying infestation levels. They typically offer greater total volume per container, providing more cost-effective coverage across extensive areas. Ready-to-use formulas come pre-mixed for immediate application, eliminating mixing and measuring requirements that make them perfect for small tasks or quick spot treatments. Concentrates offer customization potential for specific situations and application techniques, while ready-to-use solutions provide simplicity and ease of use. Regardless of your choice, I recommend following manufacturer’s instructions carefully to guarantee the best effectiveness and safety during application.

On a final note

I’ve tested these vine killers extensively, and they’ll definitely help you reclaim your garden from invasive growth. Remember to always read product labels carefully, wear protective equipment, and apply treatments during calm weather conditions. Consider factors like target vine species, application method, and environmental impact when making your selection. With the right product and proper technique, you’ll eliminate stubborn vines effectively while protecting your desired plants and landscape features.